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KMID : 0043319950180050351
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Archives of Pharmacal Research
1995 Volume.18 No. 5 p.351 ~ p.355
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Induction and Inhibition of Iindole Production of Intestinal Bacteria
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Kim Dong-Hyun
Lee Jae-Ho
Bae Eun-Ah
Han Myung-Joo
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Abstract
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The fecal tryptophanase activities were for rats and wet feces for humans. The activities of indole pyruvate degradation to indole, indole pyruvate lyase, of these feces were and wet feces, respectively. The optimal pH values of tryptophanase and indole pyruvate lyase were 5.5-7.5 and 5.5-6.5, respectively. When the intestinal flora or E. coli HGU-3 was cultured in GAM broth having six different pH values (5 to 10), the activities of tryptophanase and indole pyruvate IYilse in the medium adjusted at pH 6 were dramatically induced by elevating the pH to 9. However, when intestinal microflora were inoculated in the medium containing lactulose, the pro￢ductions of these enzymes were dramatically inhibited and the pH of the medium was lower than that of the control.
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KEYWORD
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lndole, Tryptophanse, lndole pyruvate lyase, E.coil, lntestinal bacteria
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